IGF‐I modulation of emotion and social interaction through Locus Coeruleus in aging and AD mice

Background Insulin-like Growth Factor I (IGF-I) is a peptide involved in many processes the brain. Recently, we described how IGF-I modulates sleep behavior, response to stress, and its role cognition through cholinergic, orexinergic, locus coeruleus nuclei. Nonetheless, modulation of social behavior remains explored, especially during aging Alzheimer’s disease pathology. This study aims determine emotion Locus Coeruleus activity young (<6m), middle-aged (<12m, old control (>18m), transgenic APP/PS1 DPS-4 mice, from same ages. Method We use extensive behavioral testing (Y Maze spontaneous activity) (Forced Swim Test, Elevated Plus Maze), interaction (Social affiliation novelty/Preference), another test. also electrophysiology LC responses as neurotoxin evaluate interaction. Results now report that reduced even after cognitive decline. Moreover, present similar alterations C57 mice (>18m). Further, activation electrically stimulated LH neurons by local was aged mice. Middle-age injected with DSP-4 disrupted activity. Conclusion Consequently, can activate modulate our results. Social emotional disturbances may be related resistance LC, reflecting broader loss mouse